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(3) Stage-adaptive targeting addresses evolving plaque biology [142], with PBNs unique hemodynamic stability enabling: (i) endothelial activation/neutrophil recruitment during early atherogenesis, (ii) foam cell/collagen fiber targeting in progressive plaques, and (iii) thrombus/necrotic core engagement in unstable lesions [99]
Reconstitution : add diluent along the vial wall
J Free Radic Biol Med 1985
These procedures are aimed at fast clearance of pigment, whilst it orally maintains the long term results
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