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Researchers calibrated the CORE model with baseline characteristics from LEAD-1 and projected outcomes, including survival rates, cardiovascular, ophthalmic, and renal events incidence, and healthcare expenditures over 10-, 20-, and 30-year intervals (16)(17)

However, c-MYC can also increase demethylation of the glutamine synthetase (GS) promoter under glutamine limitation and induce high expression of GS (Bott et al., 2015)