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Rather than functioning as independent mechanisms, HSPs, autophagy, mitophagy, the UPS, ERAD, and UPR collectively form a multilayered, compensatory system that preserves protein quality and cellular viability
10.1016/j.ijbiomac.2020.12.183 44 LiuT.SunL.ZhangY.WangY.ZhengJ
Particularly relevant for skin chronic inflammation breaks down collagen faster than your body can rebuild it
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