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The medications, also known as GLP-1s, have surged in popularity for weight loss but were initially developed to treat diabetes
Patients on metformin and another antihyperglycemic agent (N=229) and patients not on any antihyperglycemic agents (off therapy for at least 8 weeks, N=41) were randomized after a run-in period of approximately 10 weeks on metformin (at a dose of at least 1500 mg per day) in monotherapy
Chronic stress or toxin exposure (e.g., urban living, smoking history)
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