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Multiple in vitro studies have demonstrated that NAC actively induces the non-immunological degranulation of mast cells, causing them to dump pre-formed histamine directly into the bloodstream, which can trigger immediate allergic-type symptoms

Its also crucial to remember that 400 mcg per day is the acceptable upper intake level (UL)

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One clinical study found that using 5% topical vitamin C for six months improved signs of photodamaged skin, both on the surface and in the deeper structural layers of the skin