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In the present investigation, MTX challenge induced ER stress and UPR mainly through the PERK/CHOP pathway, consistent with previous studies on MTX-induced hepatic injury (Schmidt et al., 2022), nephrotoxicity (Song et al., 2021), and cognitive impairment (Lv et al., 2020)
This was noted in both ovariectomized, saline-treated groups (sacrificed either on the 15 th or 28 th day)
The fat cells are broken down and eliminated by the bodys natural processes
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