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References Kaur I, Das S, Chandel S, Chandel S (2025) Possible sarcopenia, sarcopenic obesity phenotypes and their association with diabetes: evidence from LASI wave-1 (2017-18)
These metabolic improvements explain why many tirzepatide users maintain weight loss better than people who lose weight through diet alone
Some reasonable criteria might be regaining more than 50% of lost weight, weight regain causing return of comorbidities (diabetes, sleep apnea, etc.), or inability to maintain behaviors without medication support despite best efforts
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