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In a phase 3 clinical trial called SURMOUNT-2, 938 obese or overweight adults with type-2 diabetes were assigned to one of three groups: a placebo, 10 mg of Mounjaro/Zepbound, or 15 mg of Mounjaro/Zepbound
In the aesthetic and fitness definition phase, patients arent looking to lose a dramatic amount of weight
This is why Walshs approach emphasizes balancing methylationnot with folates, which can worsen symptoms in undermethylated individualsbut with nutrients that rebuild the methyl cycle naturally
Some patients experience a plateau where weight loss stalls after being on the same maintenance dose for a long period
