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Eric Topol (25:29): Yeah, interesting how that plays out because it has real potential
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Glucagon may cross the bloodbrain barrier [89] (through circumventricular organs) and, when injected into the third ventricle, inhibits food intake in rodents [90] and birds [91], potentially via mechanisms that include inhibition of protein kinase A (PKA)/Ca 2+ -calmodulin-dependent protein kinase (CaMKK), AMP-activated protein kinase (AMPK) and agouti-related protein [92]
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