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Current prescribing information includes warnings related to elevated IGF-1, glucose intolerance, fluid retention, malignancy risk, hypersensitivity, and injection-site reactions. A complete safety discussion belongs in a separate article, but these limitations are essential when interpreting potential benefits
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Included studies provided evidence for a heterogenous population of patients with T2DM in terms of disease background, treatment experience, background therapies, and comorbid conditions (renal impairment and CV disease)
Response sets contained 5 to 8 response options (Mode: 7)
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