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Headaches reported during tirzepatide treatment may result from indirect effects of the drug rather than a direct neurotoxic or inflammatory reaction

Table of Contents How Weight Loss Injections Work in the Body Weight loss injections prescribed in the UK typically contain glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide (Wegovy) or liraglutide (Saxenda), or dual GIP/GLP-1 receptor agonists like tirzepatide (Mounjaro)

This is why Retatrutide is often discussed as a triple receptor model rather than a dual incretin model

tirzepatide activates the GIP and GLP-1 incretin receptors and adds a glucose-dependent insulin-secretion effect that an amylin analog does not have