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GLP-1 plays a limited role in improved glycemia shortly after Roux-en-Y gastric bypass: a comparison with intensive lifestyle modification
In other words, first-pass metabolism describes reduced bioavailability when you consume something orally
unless the 'natural flavors' include some of those preservatives
This sheds light on the importance of following specific precautions during the induction of anesthesia for patients who are peri-procedurally taking semaglutide or other GLP-1 RAs to prevent pulmonary aspiration of gastric contents [24]
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