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These largely uncharacterised risks introduce novel legal, ethical, and regulatory challenges for clinical trials, patient administration, and public health management (178)
Park HJ, Choe S, Park NC
According to 2023 CPIC pharmacogenomic guidelines, CYP2C19 poor metabolizers accumulate escitalopram at plasma concentrations equivalent to supratherapeutic doses in normal metabolizers, requiring a 50% dose reduction or an alternative antidepressant
Americal Journal of Medical Sciences, 221 , 176182
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