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[128], different fatty acid compositions including soy phospholipids, DHA, EPA, DHA-enriched phospholipids, and EPA-enriched phospholipids were administered to rats, the results showed that in the unsupplemented group, there was a decrease in BCL-2 levels and an increase in the expression of proapoptotic proteins such as BAX, Caspase-3 and Caspase-9 compared to the normal group, and supplementation of DHA-enriched phospholipids attenuated the nephrotoxicity of cisplatin without compromising its antitumor activity in mice