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Why Opioids Backfire With Repeated Use With repeated exposure, the nervous system adapts to opioids, leading to: Tolerance , requiring higher doses for the same effect (33,35) Dependence , with withdrawal symptoms when doses wear off (35) Opioid-induced hyperalgesia , a paradoxical increase in pain sensitivity (33,36) Rather than calming pain long term, opioids can sensitize the nervous system, making everyday stimuli feel more painful (33,36)
Dysregulation of these pathways can heighten oxidative stress, hinder mitophagy, and contribute to systemic inflammation
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Patient Education : This involves discussing the associated risks, such as eye redness, increased eyelash growth and thickness, iris pigmentation, long-term implications of treatments, and irreversible changes in eye color
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