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Research has shown that semaglutide can lead to long-term weight loss in people with obesity

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Through the 1990s and 2000s the GIP receptor was widely regarded as a poor drug target in metabolic disease, partly because GIP secretion is preserved or elevated in type 2 diabetes while its insulinotropic effect is blunted, and partly because GIP-receptor knockout animals were resistant to diet-induced obesity, which pointed the wrong way