Popular GLP-1 medications, including semaglutide and tirzepatide, are administered via weekly injections
Some capsules are extracted from plant extracts such as IGOB131 , Cinnamaldehyde or probiotic ingredients (such as strains containing P9 protein) stimulate intestinal L cells to secrete more endogenous GLP1, forming an "autologous hormone regulation cycle" and enhancing the sustainability of metabolic regulation
This drop of T3 levels affects BNP serum levels and, as it is experimentally suggested, has an impact on microvascular blood flow (MBF)
In cardiovascular outcome trials (CVOTs) such as Empagliflozin Cardiovascular Outcome Event Trial in Type 2 diabetes Mellitus Patients (EMPA-REG OUTCOME), CANagliflozin cardioVascular Assessment Study (CANVAS) and The Dapagliflozin Effect on Cardiovascular EventsThrombolysis in Myocardial Infarction 58 (DECLARE-TIMI 58) [6], they reduced the onset and progression of DKD, which was confirmed in the dedicated kidney trial The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE), which showed a canagliflozin-induced risk reduction for ESKD in people with DKD by 32% [7]