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According to the Mayo Clinic, parenteral vitamin B12 therapy is clinically indicated for treating deficiency caused by pernicious anemia, gastrointestinal disorders such as tropical sprue, and conditions resulting in malabsorption like pancreatic insufficiency

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(Study: Wilding et al., 2020) Administration: Both medications are available as once-weekly subcutaneous injections, which have been proven to be well-tolerated and effective in long-term weight management

In separate Phase 2 and Phase 3 trials, retatrutide at 12mg produced greater total body weight reduction than semaglutide at 2.4mg across comparable timeframes, with the difference primarily attributable to retatrutides additional glucagon receptor activation