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Receptor Binding and Downstream Signaling IGF-1 LR3 binds IGF1R with affinity similar to native IGF-1, preserving the receptor-level pharmacology while altering the pharmacokinetics

Unlike other treatments such as semaglutide and tirzepatide, which act on only one or two receptors, Retatrutide is a triple receptor agonist

Thus, further studies should be conducted exploring all aspects of GSH application along with SDF under in vivo conditions with longer follow-ups