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At the molecular level, excessive androgen receptor activation has been shown to stimulate phosphoinositide-3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) signalling pathways, promoting cardiomyocyte hypertrophy while simultaneously enhancing mitochondrial oxidative injury (73)
Los autores de la investigacin subrayaron la importancia de seguir explorando las causas de abandono y la efectividad a largo plazo de estos tratamientos, as como el impacto que tienen el acceso a la medicacin y las coberturas de seguro en los resultados de salud
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Science 335(6074):13481351 Booker J, Sieberer T, Wright W, Williamson L, Willett B, Stirnberg P, Turnbull C, Srinivasan M, Goddard P, Leyser O (2005) MAX1 encodes a cytochrome P450 family member that acts downstream of MAX3/4 to produce a carotenoid derived branch-inhibiting hormone
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