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Clinical obesity trials tested 12-week cycles
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p53 is nicknamed the guardian of the genome because it is a tumor supressor when it detects mutation in the cells DNA (which can turn the cell into cancer), it causes apoptosis (in fact, lots of cancers are associated with genetic mutations that switch off p53, meaning that p53 stops working and cant kill the cell before it forms a tumor and possibly becomes cancerous)
This pathway has been studied in several in vitro models and is under investigation as a potential therapeutic target in several cancers, including breast, ovarian, liver, and prostate 15,16,17,23
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