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Retatrutide (LY3437943) is an investigational triple-agonist (GLP-1, GIP, glucagon) and is not an approved therapy
It improves gut microbiota composition and barrier function, thereby reducing systemic inflammation, while simultaneously rebalancing lipid metabolism genes
These can range from minor issues like bloating, cramping, and allergic reactions, to more severe complications like kidney dysfunction and bronchial constriction, especially in asthmatic individuals
This is the reason that GSH varies less in the menstrual cycle than the steady states of GSH would suggest GSH: glutathione Because GSH changes very slowly when estradiol and S change, the GSH concentration at each time is a weighted average of both low and high GSH concentrations corresponding to many different S values
