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The half-life is a design feature, not a side effect of the molecule

In recent years, we added an epigenetic component to the Allostasis/Allostatic load model to describe how non-shared environmental experiences may set each individual on a somewhat different trajectory of development that determines either adaptive or maladaptive responses (behavior, systemic function and vulnerability to disease) to subsequent novel experiences as the life course unfolds [20]

By the 12 to 16-week mark, many individuals experience the full effects, which can include a significant reduction in body weight, often around 5% to 10% or more of their starting weight

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