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In human studies, conventional probiotics were unsuccessful in decreasing TMAO [63, 64]

More research is required in humans although there is some evidence supporting the use of acetyl-L-carnitine to treat mild cognitive impairment and mild Alzheimers disease

J Biol Chem 276:3555835563 Olteanu H, Munson T, Banerjee R (2002) Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase