Although the specific mechanism is not completely clear at present, from the perspective of its important regulatory role on GABAergic neurons, the abnormality of ARX may affect the normal development and function of GABAergic neurons, leading to the imbalance of brain neural circuits, thus causing ASD related symptoms (27).A substantial body of research has demonstrated that GABAergic interneurons play a crucial role in modulating synaptic plasticity, neuronal excitability, learning, and memory (28)
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It is synthesized inside cells from three amino acids glutamate, cysteine, and glycine and plays a central role in neutralizing reactive oxygen species, regenerating other antioxidants like vitamins C and E, and supporting phase II liver detoxification pathways
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