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feeding into the small intestine) may be necessary when there are severe, refractory symptoms associated with dehydration or malnutrition, but again, the evidence base for this approach is limited [65]
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The dysesthesia safety signal may prompt additional scrutiny or requests for supplemental neurological data
Patients with lower genetic sensitivity to GLP-1 signaling may benefit from starting higher doses or dual-peptide therapy (tirzepatide plus semaglutide combinations) to prevent regain, while those with high GLP1R sensitivity might maintain results on microdose protocols like PlexusDx's $129/month option
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