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10.1038/s41586-022-05323-7PMID: 29168506
Dehydrodiisoeugenol alleviates palmitate-induced mitochondrial dysfunction in human vascular smooth muscle cells through the activation of SIRT1-mediated Drp1 deacetylation
This is due primarily to its twofold increase in fibroblast proliferation and vascular tissue growth
Factors associated with successful continuation include proper dose escalation, proactive side effect management, dietary modifications, and realistic expectations about the transient nature of symptoms
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