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Jessica Duncan, who spoke in favor of peptides at the FDA meeting, now finds herself explaining to patients who've seen the headlines and want to know when these therapies will be available

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The concept of hydrophobic tagging (HyT) is similar to that of PROTAC, but instead of using a ligand to recruit a specific E3 ligase, a synthetic hydrophobic group, such as adamantane, linked to a chemical moiety that specifically recognizes the protein of interest, assumes the role of recruiter for the degradation machinery 119 (Figure 6)

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