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Clinical studies have shown that patients using Wegovy alongside lifestyle modifications experience significant and sustained weight reduction
According to a clinical study, users taking 1 mg semaglutide experienced a 0.6 % HbA1c reduction from the baseline (8.28%), and fasting blood glucose was 7.8 mmol/L from the baseline (9.6 mmol/L) in the first 4 weeks
In in-vitro experiments on neuronal cell line, a concentration-dependent increase in luteinizing hormone- realizing hormone (LH-RH) release associated with intracellular cAMP accumulation was observed, after GLP-1 analog injections, supporting an activity of GLP-1 on GnRH neurons (11)
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