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These compounds are handled exclusively in controlled research settings for in vitro and pre-clinical studies, with no applications in human or veterinary medicine

A product intended for metabolic rescue should therefore report culture oxygen, passage number, population doublings, senescence, post-thaw viability, respiration, and stress resistance whenever possible

Examples include nanoparticles delivering CSF1R inhibitors, TLR agonists, transforming growth factor-beta siRNA or other immunomodulatory agents to tumor-associated macrophages, regulatory T cells or myeloid-derived suppressor cells [78,79,80]

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