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Pickart LR
Semaglutide regulates lipid metabolism and polarization in tumor-associated macrophages (TAMs) through the PPARG/ACSL1 signaling pathway, transforming them from an M2 to an M1 polarized state to inhibit tumor progression
Additionally, the defense sought discovery and motion practice on general causationspecifically, whether GLP-1RAs can cause intestinal and bowel injuries as alleged in the Ozempic lawsuits
Given the conserved role of this pathway on lifespan, therapeutic strategies, such as insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibodies (mAb), represent a promising translational tool to target human aging
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