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Clearance is the most important pharmacokinetic parameter because it is the only parameter that controls overall drug exposure and it is used to calculate the dosage required to maintain a specific average steady-state concentration
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Pafili, K
By binding to GLP-1 receptors in the hypothalamus, they reduce appetite and promote satiety, leading to significant weight reduction in clinical trialswith newer agents achieving approximately 15% weight loss in obesity without diabetes (semaglutide) and up to 21% (tirzepatide), with somewhat lower reductions typically seen in patients with type 2 diabetes
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