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5 Regulatory mechanisms of glucose metabolic reprogramming 5.1 NRG1/ErbB signaling pathway and regulation of cardiac metabolic status At the regulatory level, in models of cardiac injury and regeneration, activation of NRG1/ErbB2 signaling has been shown to induce a metabolic shift in cardiomyocytes from fatty acid oxidation toward glycolysis, providing readily available energy and biosynthetic precursors to support cell proliferation and tissue repair
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MC3R is distributed across multiple tissues, including the central nervous system and placenta, and has been implicated in mechanisms related to hunger hormone signaling regulation and energy balance
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