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First, side-chain carboxyl groups and hydroxyl groups must be protected as amides or esters

DMI Opinion As per DataM, the major hurdle in the Global Oral Obesity Drugs Market is not to generate demand, but the capacity of the players to demonstrate enduring clinical efficacy along with ease of use and acceptance among patients/payers in an extensively reviewed therapy area

However, a high-fat diet and subsequent development of NASH can downregulate hepatic GLP-1R expression, thereby inducing therapeutic resistance to this medication in certain patients (Svegliati-Baroni et al., 2011

10.1080/10739680701641421 199 McleodJ