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These studies aim to improve understanding of how endocrine systems coordinate complex metabolic responses
Forced expression of wild-type Sirt1 in the mediobasal hypothalamus by adenovirus microinjection suppresses FoxO1-induced hyperphagia, which is a model for central insulin resistance (Sasaki et al., 2010)
Inflammatory markers decrease within the first three to six months
PKA phosphorylates hormone-sensitive lipase (HSL), promoting the hydrolysis of triglycerides into free fatty acids (FFA) and glycerol
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