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GLP-1 receptor agonists and mental health
Both incorporate glucagon receptor agonism alongside GLP-1 activity, but retatrutide takes this further by adding a third target -- GIP receptor agonism -- making it the first triple-hormone receptor agonist in clinical development
Moreover, plasma from individuals with T2DM showed mild but significant elevations in ketone bodies , inversely associated with insulin resistance measured by the Lipoprotein Insulin Resistance Index (LP-IR)
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