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In addition, GLP-1R is moderately in the lung, heart, kidney, blood vessels, pancreatic alpha cells, and peripheral nervous system, with no expression of GLP-1R in liver, skeletal muscle or adipose tissue (109112)
Results: nejm.org/doi/full/10.10 #ADA2023 Retatrutide, a TRIPLE agonist (GLP1, GIP, glucagon), just released phase 2 trial results demonstrating 25% weight loss in half of people with #obesity
The high neutrophil to lymphocyte ratio in critically ill patients, the intense neutrophil infiltration in pulmonary capillaries and into pulmonary alveoli, and the increased levels of circulating neutrophil extracellular traps (NETs) clearly show neutrophil involvement/activation favoring intense ROS production and oxidative damage caused by lipid peroxidation, and protein and DNA oxidation (Komaravelli and Casola, 2014
