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Lixisenatide is a long-lasting GLP-1R agonist that crosses blood-brain barrier at very low doses (Hunter and Holscher, 2012)
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Example progression: Baseline: 3 sets x 12 exercises = 36 total sets per session On IGF-1 LR3: 4 sets x 12 exercises = 48 total sets (33% increase) OR add 1-2 extra training sessions per week Prioritize compound movements: Squats, deadlifts, bench press, rows, overhead press These recruit maximum muscle fibers IGF-1 preferentially supports most-stimulated muscle tissue Shorten rest periods: Normal: 2-3 minutes between heavy sets On IGF-1 LR3: 60-90 seconds (enhanced recovery) Creates greater metabolic stress additional growth stimulus Nutrition Optimization Protein: 1.2-1.5g per pound of body weight IGF-1 LR3 increases muscle protein synthesis rates by 30-50%
5 Common Reasons Your Weight Loss Has Slowed 1
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