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Similarly, as the genetic deficiency of vacuolar protein sorting protein 18 (VPS18) is reported to facilitate the lysosomal degradation of LOX, the impaired dendritogenesis in VPS18 knockout mice was suggested to be correlated with the accumulation of LOX (52)

[1] [3] Hypersensitivity to cobalt or any cobalamin is a contraindication to B12 injections

Stability in aqueous nasal spray form is a real and under-discussed problem: no published stability data exist for commercial nasal formulations of BPC-157