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A high percentage of cells in S-phase is associated with a better clinical response to MTX (11) and is accompanied by increased expression of genes involved in nucleotide biosynthesis, such as TYMS , CPTS , and an MTX target enzyme, DHFR ( 11)
doi 10.2147/jir.s152835 86 SunHShuJTangJLiYQiuJDingZet al
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Blocks Melanin Production: It blocks an enzyme known as tyrosinase
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