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Toxicological study of bee venom ( Apis mellifera mellifera) from different regions of the province of Buenos Aires, Argentina
& Morio, B
It is well known that an enzyme simultaneously presented with two alternative substrates will catalyze their reactions in the ratio between their respective catalytic efficiency multiplied with the ambient substrate concentration, k cat /K m [substrate]
While each of these peptides has been studied individually in various in vitro and preclinical models , combining them is hypothesised to offer complementary modes of action
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