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Participants can report suspected side effects to the MHRA Yellow Card Scheme and may withdraw from a trial at any time without affecting their standard NHS care
Semaglutide is a synthetic 31-amino-acid analogue of the human incretin hormone glucagon-like peptide-1 (GLP-1), engineered to resist enzymatic degradation and bind serum albumin
Isotretinoin has been associated with premature epiphyseal closure, hyperostosis, and decreased bone mineral density in case reports, particularly with prolonged or repeated courses [14]
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