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The STEP 1 extension study showed that participants who discontinued semaglutide after 68 weeks regained approximately two-thirds of the lost weight within one year

Analysis of clinical chemistry parameters measured at the end of the 4-week study (Supplementary Table 11) showed that MEDI4166 treatment reduced FPG, total cholesterol and serum alanine transaminase (ALT) levels, which is indicative of improved liver function

Patients should be counselled on gradual dose escalation to minimise these effects

Improvements in quality of life scores were found in patients with HFrEF but not in those with HF with preserved ejection fraction