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Renal impairment was defined as mild with eGFR values of 6089 mL/min, moderate eGFR 5930 mL/min and severe with eGFR values 56 mol/l, can lead to encephalopathy and status epilepticus [34, 35], whilst in most people ASM-induced HA is of minor clinical significance

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In the UK, the storage and handling of licensed medicines is governed primarily by the Medicines and Healthcare products Regulatory Agency (MHRA) , with clinical guidance on specific therapeutic areas provided by the National Institute for Health and Care Excellence (NICE) and the NHS

Compounding refers to custom-made medications prepared by specialized pharmacies rather than standardized FDA-approved drugs [9]