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While freezing did not impact the concentrations of NAD + , NADH, GSH, or GSSG, it triggered the conversion of NADPH to NADP + , with about 508% of NADP + originating from NADPH oxidation (Supplementary Figure 1m-r)

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Inputs: total calcium, albumin

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It makes the molecule more prone to aggregation, the process where peptide molecules clump together and lose their individual functionality

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