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Combination therapy in PCOS has demonstrated additive benefits on weight and menstrual cyclicity, highlighting synergistic mechanisms rather than direct reproductive pharmacodynamics

For one of these derivatives, authors obtained interesting results

The timing is annoying

The safety profile of cagrilintide-semaglutide was broadly consistent with that reported for other incretin-based therapies, although gastrointestinal adverse events and treatment discontinuations occurred more frequently than with either semaglutide or cagrilintide alone, highlighting the importance of careful patient selection and long-term adherence