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It is FDA-approved for weight loss and long-term weight management in adults and adolescents 12 years and older with obesity, as well as adults with overweight who have at least one weight-related health condition
It has been found that the thioredoxin reductase system and glutathione peroxidase system play an important role in cellular oxidative stress defense (Lee et al., 2012
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Certain variants may correlate with greater gastric sensitivity or slower baseline emptying rates, though genetic predisposition does not determine exact medication response
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