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Studied use areas Tendon, ligament and musculoskeletal recovery (research context) Gastrointestinal barrier and mucosal integrity (research context) Wound-healing and tissue-perfusion signalling Angiogenesis and local circulation during recovery Inflammation balance in the healing microenvironment Safety & status Investigational and not an approved medicine

Interestingly, other B vitamin interventions have found negative effects, such as increased rates of vascular events and kidney decline ( JAMA 2010;303:1603-1609)

the risk is lower than after malabsorptive procedures as no bowel is bypassed