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In pancreatic beta cells, GLP-1RA promotes the conversion of proinsulin to mature insulin by upregulating the expression of hormone converting enzymes PC1/3 and PC2, while reducing the proinsulin/insulin ratio and enhancing insulin biological activity
Practitioners may consider AOD 9604 in investigational protocols where IGF-1 elevation is a concern, recognizing that AOD 9604 has no regulatory approval and a narrower, largely preclinical record of efficacy
H., Nielsen, P
[cited 2023 Nov 14]
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