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When using a skin-lightening cream, follow the instructions provided by your doctor or on the packaging, which may include: Applying the product sparingly with clean hands or a cotton pad Avoiding contact with surrounding skin, eyes, nose, and mouth Washing hands thoroughly after use Avoiding contact with treated areas and others' skin Applying sunscreen to prevent UV damage Many skin-lightening products available on the market are used once daily, although there is no evidence supporting their effectiveness